Over the course of the past week, numerous articles have been appearing concerning Neanderthal DNA and its presences in our modern genome. There are actually three studies that were done by 3 independent teams. Pretty kewl stuff if you like science,,,
IT IS surprising what a little hanky-panky can do. A handful of sexual encounters between humans and Neanderthals made many of us what we are today, affecting both our appearance and our vulnerability to disease. But the genetic legacy left by the Neanderthals also highlights just how different we are from our sister species.
Neanderthals lived in Europe and Asia between about 200,000 and 30,000 years ago. Our species – sometimes dubbed "modern humans" – made it to Eurasia about 65,000 years ago, and so the two species had plenty of time to cosy up. In 2010, geneticists discovered that they had been very close neighbours indeed. They sequenced a Neanderthal genome and discovered it carried genes that also appear in the genomes of people of European and Asian descent: our species must have interbred with Neanderthals.
Now, by studying Neanderthal genes in people alive today, researchers are beginning to appreciate how that interbreeding influenced our species.
In one new study of 1000 human genomes, Sriram Sankararaman and David Reich of Harvard Medical School and colleagues found that Neanderthal DNA is most common in regions of the genome with the greatest genetic variability, making them a prime target for natural selection. While Neanderthal DNA may make up only 1.6 to 1.8 per cent of the Eurasian genome, it punches above its weight in terms of biological impact, says Reich (Nature, DOI: 10.1038/nature12961).
Joshua Akey and Ben Vernot of the University of Washington in Seattle have analysed the Neanderthal DNA in a further 665 humans (Science, DOI: 10.1126/science.1245938). Both their study and the Harvard one found a hotspot of Neanderthal ancestry in genes relating to keratin, a fibrous protein found in our hair, skin and nails.
,,,A third study published this week describes a DNA analysis of one person who lived in Stone Age Europe about 7000 years ago – 40,000 years after any Neanderthal interbreeding. His genes suggest his skin was dark (Nature, doi.org/q74). It may be that the Neanderthal keratin affected early Eurasians' hair instead, perhaps straightening it.
Neanderthal-human sex bred light skins and infertility - life - 29 January 2014 - New Scientist
See also:
Surprise! Ancient European had dark skin and blue eyes, DNA reveals
Hello, Neanderthal! Yes, This Means You.
New studies reveal 20 Percent of Neanderthal genome lives on in modern humans
Fifth of Neanderthals' genetic code lives on in modern humans
Kissing cousins
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