Wednesday, April 22, 2020

It's not that simple, Jillian

So you make the claim, “[h]ormonal imbalances create high blood pressure, not sodium.” Then offer this partial screen grab as citation, Plain water has surprising impact on blood pressure.  
You really lack in the nuance department there Jillian. First, the "Effects" portion, is a totally different cite; which remains unknown.  Second, the ramifications of this research deals primarily in the prevention of fainting among those who donate blood. As the article states,
These findings prompted the American Red Cross to conduct a study of water drinking as a method for reducing fainting responses. The study found that drinking 16 ounces of water before blood donation reduced the fainting response by 20 percent.

“This response to water may turn out to be very important for retaining blood donors,” Robertson said. “If you pass out after giving blood, you pretty much never give blood again. If we can reduce fainting by 20 percent, we can reduce the unpleasantness of passing out and really bolster the number of people who can continue to be blood donors.”
Let's have a look-see at the entire article.

Jilly Juice is not plain water.

Researchers at Vanderbilt University Medical Center have shown that ordinary water — without any additives — does more than just quench thirst. It has some other unexpected, physiological effects.

So right from the start, another worthless screen grab that doesn't discuss anything relevant to Jilly Juice.  This is why cherry-picking information is so bad. You don't get to make shit up as you go along.

This article discusses findings, reported in the June 2010 issue of the journal Hypertension, concerning water's ability to “increase the activity of the sympathetic nervous system,,, which raises alertness, blood pressure and energy expenditure.”
Although water does not significantly raise blood pressure in healthy young subjects with intact baroreflexes, the investigators found that it does increase sympathetic nervous system activity and constrict blood vessels (which prevents pooling of blood in the extremities),,,The investigators ultimately determined that water dilutes the plasma in the blood vessels leading away from the duodenum and that this short-lived reduction in salt concentration (hypo-osmolality) is responsible for water's blood pressure-raising (pressor) effect. They implicated a protein called Trpv4 in the mechanism: mice lacking the Trpv4 gene did not have a pressor response to water.
No mention of “[h]ormonal imbalances create high blood pressure.”  It disuses the consumption of water.

FYI, the actual paper::  Portal Osmopressor Mechanism Linked to Transient Receptor Potential Vanilloid 4 and Blood Pressure Control

So the second grab you display, 

is not from the article noted above. but from Lower Your Blood Pressure Naturally by Drinking Water by Dr. Stephen Sinatra.

In the article, Sinatra lists suggestions for proper hydration. It does not include Jilly Juice nor does it mention hormone imbalances.

DON'T overdo it. While I want you to get the health benefits of drinking water, I don't want you to go overboard. Like a sponge, your body can absorb water at a limited rate. It will require some time to adapt to your new level of water intake and become fully hydrated. Drinking too much water can overwork your kidneys and digestive system,,,
Previous to that point Sinatra notes this.
How does not drinking enough water raise your blood pressure? Water intake affects blood pressure in two ways. First, when you don’t drink enough water your body attempts to secure its fluid supply by retaining sodium. Sodium is your body’s “water-insurance mechanism.”
Stated plainly, where salt (sodium) goes water follows.  Under the recommended RDA, this maintains a well regulated homeostasis.
At the same time, dehydration forces your body to gradually and systematically close down some of its capillary beds. When some capillary beds shut down, it puts more pressure in the “pipes”—your capillaries and arteries—elevating your blood pressure. So, one of the best ways to lower your blood pressure naturally is by staying well-hydrated.

Out of curiosity, I checked further as to Sinatra's suggested intake of salt and found this, Lower Your Blood Pressure By Eating More Salt, Not Less?
Excess salt causes high blood pressure by promoting water retention, which increases your blood volume and raises your blood pressure.
Sinatra continues.
For years, doctors have said that for healthy blood pressure you should limit your salt to just 2,300 mg a day. But studies have shown that eating too little salt can be just as dangerous as eating too much.
So it sounds like Sinatra is not a firm believer in the RDA of 2300mg/day. Not unusual, as both Dr Schierling and Dr DiNicolantonio, oft cited by you and your minions also advocate for a higher amount; up to 6000mg/day.
 
Still well below what you advocate.
A review of the Framingham Offspring Study found that too little sodium (less than 2,500 mg daily) raised blood pressure higher than it did for those who were eating higher amounts.
Your slop contains ~6900mg/2cup recipe. Almost 1.5X what Sinatra suggests.
The problem is that excessive salt restriction can cause dangerously high renin levels, a hormone secreted by the kidneys that regulates water and blood pressure balance. High levels of renin can cause the renal arteries to tighten and constrict, resisting blood flow and elevating blood pressure.
While Sinatra does speak of the hormone renin, one must keep it in context – he is not suggesting one consume more than 2500-3000 mg of salt per day.  And is careful to note,
While one size doesn’t fit all, for healthy blood pressure you want to aim for about 2.8 grams of sodium a day.
One point Sinatra does make,
Skip the Olives, Pickles & Sauerkraut: These foods are loaded with sodium. A single large black olive, for example, contains 32 mg of sodium. And a medium-sized dill pickle can pack a whopping 785 mg.
Another point you note, as I couldn't find a direct source for this statement I am assuming you are the source.

“Antidiuretic hormone (ADH), a hormone produced by the hypothalamus and released by the posterior pituitary, raises blood pressure by stimulating the kidneys to retain H 2O (raising blood pressure by increasing blood volume).” 

While what you state is correct, it is overly simplistic and vague. For a complex subject as ADH regulation you neglect much information.

Its most important role is to conserve the fluid volume of your body by reducing the amount of water passed out in the urine. It does this by allowing water in the urine to be taken back into the body in a specific area of the kidney. Thus, more water returns to the bloodstream, urine concentration rises and water loss is reduced. Higher concentrations of anti-diuretic hormone cause blood vessels to constrict (become narrower) and this increases blood pressure. A deficiency of body fluid (dehydration) can only be finally restored by increasing water intake.
So the release of ADH is a specific reaction to specific conditions within the body. A point your initial statement ignores.
High levels of anti-diuretic hormone cause the kidneys to retain water in the body. There is a condition called Syndrome of Inappropriate Anti-Diuretic Hormone secretion (SIADH; a type of hyponatraemia) where excess anti-diuretic hormone is released when it is not needed,,, With this condition, excessive water retention dilutes the blood, giving a characteristically low salt concentration. Excessive levels of anti-diuretic hormone might be caused by drug side-effects and diseases of the lungs, chest wall, hypothalamus or pituitary. Some tumours (particularly lung cancer), can produce anti-diuretic hormone.
,,,
Low levels of anti-diuretic hormone will cause the kidneys to excrete too much water. Urine volume will increase leading to dehydration and a fall in blood pressure. Low levels of anti-diuretic hormone may indicate damage to the hypothalamus or pituitary gland, or primary polydipsia (compulsive or excessive water drinking).
IOWs excessive diarrhea, aka waterfalls, bypasses this function causing dehydration. Stated another way,
ADH constantly regulates and balances the amount of water in your blood. Higher water concentration increases the volume and pressure of your blood. Osmotic sensors and baroreceptors work with ADH to maintain water metabolism.
What is important to to bear in mind, and something you don't do Jillian, the regulation of various body functions are  tightly controlled with minimum and maximum ranges.  Those functions are not as simplistic as you make them appear.
Roughly 60% of the mass of the body is water, and despite wide variation in the amount of water taken in each day, body water content remains incredibly stable. Such precise control of body water and solute concentrations is a function of several hormones acting on both the kidneys and vascular system, but there is no doubt that antidiuretic hormone is a key player in this process.
Yes, ADH is a hormone, and yes it does effect BP – on both ends of the spectrum. But, it is one of 200+ hormones in the human body, and works in conjunction with other processes and internal conditions within the body.
The most important variable regulating antidiuretic hormone secretion is plasma osmolarity, or the concentration of solutes in blood.

When plasma osmolarity is below a certain threshold, the osmoreceptors are not activated and secretion of antidiuretic hormone is suppressed. When osmolarity increases above the theshold, the ever-alert osmoreceptors recognize this as their cue to stimulate the neurons that secrete antidiuretic hormone.

Osmotic control of antidiuretic hormone secretion makes perfect sense. Imagine walking across a desert: the sun is beating down and you begin to lose a considerable amount of body water through sweating. Loss of water results in concentration of blood solutes - plasma osmolarity increases. Should you increase urine production in such a situation? Clearly not. Rather, antidiuretic hormone is secreted, allowing almost all the water that would be lost in urine to be reabsorbed and conserved.
So, read another way, shitting your brains out via waterfalls is not a good idea. In healthy humans, ADH has minimal effect and is not a concern. You, OTOH Jillian, over generalize that everyone has an issue when that is not the case.

So “[d]rink water” while a good suggestion to maintain hydration, is not the solution.

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